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KMID : 1059520130570040493
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Journal of the Korean Chemical Society
2013 Volume.57 No. 4 p.493 ~ p.498
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Ultrasound-Triggered Drug Release of Hydroxyapatite Coated Liposomes
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Cho Sung-Keun
Wee Tae-In
Ha Jeung
Cho Sun-Hang
Han Kun
Han Hee-Dong
Shin Byung-Cheol
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Abstract
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Liposomes, which can deliver payload at target site, have been studied as drug carrier. However, conventional liposomes have limitation for drug release at target site. Therefore, we developed hydroxyapatite (HA) coated ultrasound sensitive liposomes to increase drug release at target site and to enhance stability in blood stream. Control liposome was prepared using hydrogenated soy phosphatidylcholine (HSPC) and cholesterol, and then we assessed HA coating on the surface of control liposomes using calcium acetate, phosphoric acid, and 25% ammonium solution. Doxorubicin was used as a model drug. Size of HA coated liposomes was 120 nm and encapsulation efficiency of doxorubicin in liposomes was up to 95%. Size of HA coated liposomes are not changed in 30% serum solution, however, the control liposomes was 1.4 fold increased. After ultrasound triggered drug release from liposomes, intracellular efficiency of drug released from HA coated liposomes was 3 fold increased compared to control liposomes. In this study, we developed ultrasound sensitive liposomes to enhance drug release, which will be applied in controlled drug release at disease site.
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KEYWORD
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Hydroxyapatite, Liposome, Ultrasound, Drug release, Stability
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